What is 5-HTP?

5-HTP, or 5-hydroxytryptophan, is a natural substance that can normalize sleep, improve mood, and increase resistance to stress.

5-HTP comes from the seeds of an African shrub known as Griffonia simplicifolia. This amino acid is an intermediate product in the metabolism of tryptophan, one of the essential amino acids.

It is not produced in the human body, so it must be supplied with food. Tryptophan can be found in protein-rich foods, such as dairy products, poultry, meat, chocolate, nuts, legumes, caviar, and certain types of fish. Often this amount of amino acid is not enough and it can be provided with 5-HTP dietary supplements.

5-HTP is a chemical precursor of serotonin and melatonin. Low serotonin levels are associated with depression, anxiety, sleep disorders, weight gain, and other health problems. Thus increasing your body’s production of serotonin has various benefits.

What are the Benefits and Effects of 5-HTP?

• 5-HTP helps with depression by increasing serotonin levels. Serotonin imbalance may lead to depression. 5-HTP supplements are thought to act as antidepressants and treat depression by increasing serotonin levels. 5-HTP helps to get rid of irritability, aggressiveness, and lethargy and can reduce anxiety and nervous tension.
• It relieves symptoms of fibromyalgia. Supplementing with 5-HTP may improve symptoms of fibromyalgia such as general weakness and muscle and bone pain. Low serotonin levels are associated with the disorder.
• It can help reduce migraine frequency. 5-HTP is said to help with migraines which are often accompanied by nausea or disturbed vision. While their exact cause is debated, some researchers believe migraines are also triggered by low serotonin levels.
• 5-HTP can improve sleep by increasing melatonin production. Serotonin is converted into the hormone melatonin that regulates sleep.
• 5-HTP can aid weight loss by increasing the feeling of fullness. 5-HTP may counteract hunger-inducing hormones, working to suppress appetite and help you lose weight. 5-HTP may also reduce excessive food intake due to stress or depression.

What is 5-HTP Used For?

The main indications for the use of the drug are:

• depression;
• sleep disorders;
• chronic fatigue;
• migraine;
• alcoholism and drug addiction;
• excess weight.

In addition, the 5-hydroxytryptophan will be useful during stressful periods of life that require efficiency and concentration.

Where Can I Order 5-HTP Online?

You can buy 5-HTP online from different vendors. CosmicNootropic offers 5-HTP in packs of 30 pills. We offer worldwide shipping! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order 5-HTP and get it delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.

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This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more

BrainMax is a new combination nootropic for neuroprotection in the effective injection form. It contains two nootropics – Meldonium and Mexidol –  and each of them enhances the effects of the other. It also can be useful in the rehabilitation of patients with post-COVID syndrome.
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What is BrainMax?

BrainMax is a combination preparation that contains Meldonium and ethylmethylhydroxypyridine succinate (also known as Mexidol). Meldonium is known for treating and preventing cardiovascular diseases and for its use as a performance enhancer in sports due to improving tissue oxygenation. Mexidol is a free radical inhibitor and membrane protector with antihypoxic, stress-protective, nootropic, anticonvulsant and anxiolytic action.

BrainMax uses the synergy of the two components to protect, maintain and restore cells of the nervous system and brain under extreme conditions of the lack of oxygen, including cases of infections and post-infection period.

BrainMax is a brand-new drug that hit the pharmaceutical market only recently. If you’re interested in learning more about the scientific research behind this preparation check the Research tab above.  

What are the Benefits and Effects of BrainMax?

A wide range of BrainMax effects is defined by the effects of its components and includes:

• stress-protective;
• anti-hypoxic;
• antioxidant;
• nootropic;
• anti-ischemic.

The combination of meldonium and ethylmethylhydroxypyridine succinate in BrainMax enhances the above-mentioned effects and benefits. That is what makes this drug stand out among nootropics with similar effects.

What is BrainMax Used For?

BrainMax can be used in complex therapy:

• For the treatment of acute and chronic disorders of brain blood circulation;
• Improvement of cognitive functions (memory and attention);
• Normalization of emotional state and mood improvement;
• Maintenance of ability to work;
• Support of the body at mental and physical overload, including in sports*.

*Meldonium which is one of the components of BrainMax is included in the prohibited list of the World Anti-Doping Agency as it is believed to improve sports performance and affect competition results.

Thus it is not recommended to take it prior to professional competitions.

Can I Use BrainMax for Covid Rehabilitation?

BrainMax can be of use in the rehabilitation of patients after COVID-19, according to the producer’s information. Phase III of clinical trials of therapy with Brainmax to treat patients with asthenia after COVID-19 is underway.

According to the registry, the studies involve 200 patients at six medical institutions and are scheduled for completion by December 31, 2022 [4].

Where Can I Order BrainMax Online?

You can order BrainMax online from different vendors. CosmicNootropic offers BrainMax in packs of 10×2.5ml vials. We offer worldwide shipping with volume discounts! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order BrainMax and get it delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.

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This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
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What is inside the Adaptogens Bundle?

Adaptogens Bundle contains samples of five bestsellers that we have hand picked for you based on their effectiveness and safety.

How to take Adaptogens Bundle?

The optimal way to take adaptogens in the bundle is in sequence, with 2-3 week intervals. In this manner, you can track the effects and pick out an adaptogen or a stack that works best for you.

Why shall I buy Adaptogens bundle?

This product is for those who like to try popular membrane protectors, performance boosters, and anti-hypoxic medications or who look for the perfect adaptogenic stack. Since every person is unique, you can learn which product is right for you only after sampling it. Take a serious approach to your well-being and health, try out this Adaptogens Bundle.

What are the benefits of Adaptogens Bundle?

• First of all, the supplements in the Bundle have been extensively studied and used in post-Soviet countries and each of them has dozens of papers on Pubmed.
• Secondly, they are produced officially by reputable manufacturers in compliance with local and international requirements.
• Thirdly, this adaptogens sample pack is money-saving as you get 5 bestsellers at 1/3 of the price you would spend if you bought them separately.

Why do healthy people take Adaptogens?

Healthy individuals may find Adaptogens useful if they need to run sustainable energy levels without major dips. Coffee, cigarettes and other stimulants can put much stress on the nervous system and their effect is short-lived. The products in the Adaptogenic bundle have a different, more profound mechanism of action. They are not stimulants in the conventional sense. Adaptogens are intended to be used in a course, during and after which the energy is restored to the normal level.

Also, check out nootropics and anxiolytics bundles.

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This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more

]]> https://cosmicnootropic.com/products/adaptogens-bundle/feed/ 0 https://cosmicnootropic.com/products/anxiolytics-bundle/ https://cosmicnootropic.com/products/anxiolytics-bundle/#respond Mon, 19 Dec 2022 19:23:34 +0000 https://cosmicnootropic.com/?post_type=product&p=96172 Buy Anxiolytics Bundle to find your perfect anxiolytic supplement or stack without spending lots of money. The Anxiolytics Bundle contains five most popular anti-anxiety products that can help you deal with stress in a healthy way. Choose the one that works best for you. US fast delivery and international shipping available!]]> Anxiolytics are supplements that reduce and prevent anxiety and related symptoms. They are popular among people who are looking to have a calming effect, reduce irritability, elevate mood and improve sleep quality.

What is inside the Anxiolytics Bundle?

Anxiolytics Bundle contains samples of five bestsellers that we have hand-picked for you based on their effectiveness and safety.

How to take Anxiolytics Bundle?

The optimal way to take anxiolytics in the bundle is in sequence, with 2-3 week intervals. In this manner you can track the effects and pick out an anxiolytic or a stack that works best for you.

Why shall I buy Anxiolytics Bundle?

This Bundle is for those who like to try popular anti-anxiety medications and mood-elevators or who look for the perfect anxiolytic stack. Since every person is unique, you can learn which product is right for you only after sampling it. Take a serious approach to your well-being and health, try out this Anxiolytics Bundle.

What are the benefits of Anxiolytics Bundle?

• First of all, the supplements in the Bundle have been extensively studied and used in the post Soviet countries and each of them has dozens of papers on pubmed.
• Secondly, they are produced officially by reputable manufacturers in compliance with local and international requirements.
• Thirdly, this anxiolytics sample pack is money-saving. You get 5 bestsellers at 1/3 of the price you would spend if you bought them separately.

Why do healthy people take Anxiolytics?

We often face stress in the everyday life. Sometimes the stress levels run so high that people find themselves resorting to alcohol, smoking and other ways to feel better. But this is not the healthiest way of dealing with stress. Do you want to give up your bad habits and maintain both mental and physical health? With Anxiolytics this process is going to be much more effective and much easier for you.

Also, check out Nootropics and Adaptogens bundles.

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This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more

Looking for a gift idea for your fellow nootropic enthusiast? Not sure which nootropic supplements to choose as a gift?

CosmicNootropic offers virtual gift cards to make the task of finding the best present much easier. With these nootropics gift cards, there is no way to choose the wrong items — only what your recipients would pick themselves.

What is more, such a present is easy to send. The Nootropics Gift Card will be immediately delivered to your recipient’s email. No worries about holiday shipping delays or international packages stuck in customs.

What Options Can I Choose with Nootropics Gift Cards?

We offer nootropics gift cards from $50 to $500. Choose the amount you want and add it to your Cart.

How Long Can I Use Nootropics Gift Cards?

Every gift card is valid for one year starting from the purchase date. However, if your card expires and you need more time, drop us a line — we can extend it.

What is inside the Nootropics Bundle?

Nootropics Bundle contains samples of five bestsellers that we have hand-picked for you based on their effectiveness and safety.

How to take Nootropics Bundle?

The optimal way to take nootropics in the bundle is in sequence, with 2-3 week intervals. In this manner, you can track the effects and pick out a nootropic or a stack that works best for you.

Why shall I buy Nootropics Bundle?

This Bundle is for those who want to try popular cognitive enhancers and neuroprotectors or those who look for the perfect nootropic stack. Since every person is unique, you can learn which product is right for you only after sampling it. Take a serious approach to your well-being and health, try out this Nootropics Bundle.

What are the benefits of Nootropics Bundle?

1. First of all, the supplements in the Bundle have been extensively studied and used in post-Soviet countries. And each of them has dozens of papers on Pubmed.
2. Secondly, the pharmaceuticals in the Bundle are produced officially by reputable manufacturers in compliance with local and international requirements.
3. Thirdly, this nootropic sample pack is money-saving. You get 5 bestsellers at 1/3 of the price you would spend if you bought them separately.

Why do healthy people take Nootropics?

If you are a relatively healthy individual and you want an edge in improving your brain functions, take a closer look at nootropics. They help create new neural connections via NGF and BDNF which emerge in the body under the influence of nootropics. This process is important both for learning and for dealing with bad habits, or in other words for replacing old neural connections with new ones. That is where the Nootropics bundle may turn out to be useful.

Also, check out anxiolytics and adaptogens bundles.

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This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more

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What is Theanine?

L-Theanine is an amino acid similar in structure to the neurotransmitter L-glutamate. This substance was first extracted from green tea leaves in 1949. Theanine passes through the blood-brain barrier. And it has been shown to have a neuroprotective effect.

Theanine works as a brain activator. But at the same time, it does not cause excitability of the nervous system. On the contrary, it allows one to keep calm, have clarity of mind, and reduce stress.

What are the Benefits of Taking Theanine?

Theanine is a bioactive compound with plenty of health benefits, including antioxidant, anti-inflammatory, neuroprotective, anticancer, metabolic regulatory, cardiovascular protective, liver and kidney protective, immune regulatory, and anti-obesity effects.

The benefits of L-Theanine declared by the manufacturer are:

• Reduction of stress, anxiety, and irritability;
• Normalization of blood pressure in stressful situations;
• Improvement of concentration and cognitive functions;
• Strengthening of the immune system;
• Increase in dopamine, a hormone that improves mood and increases endurance during physical training.

What is L-Theanine Used For?

L-Theanine as a food supplement can be used to:

• Reduce the impact of stress on the body;
• Improve cognitive functions and abilities;
• Improve a person’s emotional state;

Studies show a lot of applications of L-Theanine in clinical practice. L-Theanine is said to treat attention deficit hyperactivity disorder (ADHD) [4,6], slight cognitive dysfunction [3], and even cancer [5,9,13].

Where Can I Order Theanine Online?

You can buy Theanine online from different vendors. CosmicNootropic offers Theanine in packs of 30x500mg pills. We offer worldwide shipping with volume discounts! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Theanine and get it delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.

Legal Disclaimer
This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more

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What is Tenoten?

Tenoten is a homeopathic drug that is claimed to produce anxiolytic and nootropic effects.

The manufacturer claims that the mechanisms of these effects are attributed to the antibodies against S-100 protein: at ultra-low doses, they exert GABA-mimetic and neurotrophic actions, up-regulate stress-limiting systems and contribute to the restoration of neuroplasticity. However, many people say that the effect of this drug is mostly attributed to a placebo effect because the amount of the active ingredient is too small to have any effect.

What is the Mechanism of Action of Tenoten?

The drug modifies the functional activity of the S-100 protein, which conjugates the synaptic and metabolic processes in the brain. Due to its GABA-mimetic and neurotrophic action, the drug increases the activity of stress-limiting systems and contributes to the restoration of neuronal plasticity.

What are the Benefits and Effects of Tenoten?

• Tenoten has a calming, anxiolytic action without causing undesirable hypnogenic and muscle relaxant effects.
• Tenoten improves the tolerance to psychoemotional loads.
• Tenoten has a stress-protective, nootropic, anti-amnestic, anti-hypoxic, neuroprotective, anti-asthenic, antidepressant action.
• In case of intoxication, hypoxia, or after an acute disturbance of cerebral blood circulation, Tenoten has a neuroprotective effect, limits the damage zone, and normalizes learning and memory processes in CNS.
• Tenoten inhibits the processes of lipid peroxidation.

What is Tenoten Used For?

Tenoten is used to treat the following functional disorders:

• Neurotic and neurosis-like disorders;
• Psychosomatic diseases;
• Stress-induced disorders with increased tensions;
• Irritability, anxiety, and autonomic reactions;
• Mild to moderate organic CNS disorders.

Where Can I Order Tenoten Online?

You can buy Tenoten online from different vendors. CosmicNootropic offers Tenoten in packs of 40x3mg pills. We offer worldwide shipping with volume discounts! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Tenoten and get it delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.

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This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more

Etifoxine (trade name Stresam) is an anxiolytic and anticonvulsant medication developed in the 1960s and used ever since. Its benefits are similar to those of benzodiazepines, but Stresam is considered to be much safer.

Check other products from the ANTI-ANXIETY category.

What is Stresam?

Stresam is an anxiolytic drug manufactured by the French company Biocodex. The drug is approved in more than 40 countries. Its active substance is etifoxine. It is a benzoxazine derivative. It is characterized by maximum selectivity and physiological action.

The active substance was developed back in the 1960s by the German pharmaceutical company. Back then benzodiazepines (diazepam, oxazepam, phenazepam), which are psychoactive substances with sedative effects, dominated the market. However, it is a well-known fact that tranquilizers of the benzodiazepine structure have significant side effects. Etifoxine was one of several anxiolytics with enough potential to replace benzodiazepine drugs.

The compound produces neurosteroids in the brain that can indirectly modulate the activity of the GABAA response. Enhancing neurosteroids in the brain has a lot of potential in keeping the functional yet calm state of body and mind.

What are the Benefits of Stresam (Etifoxine)?

• The drug effectively eliminates manifestations of anxiety: fear, stress, discomfort, insomnia, inner tension, etc.
• Etifoxine does not have a withdrawal syndrome and does not cause dependence. Hence it can be of interest to narcologists. Stresam has shown its effectiveness in the reduction of manifestations of alcohol withdrawal, tremors, and paroxysmal sweating. Also, Stresam helps to reduce the pathological craving for alcohol, improving the quality of life in the post-withdrawal period.
• Some state that Stresam may also exhibit nootropic benefits like improvement in concentration and memory functions. This is attributed to the fact that Stresam is said to stimulate mitochondrial benzodiazepine receptors, thereby enhancing the synthesis of neurosteroids.
• Another property of Stresam that has been recently discovered is neuroprotection. Stresam was shown to promote neuron growth; in particular, it accelerates axonal regeneration and may serve as a treatment for polyneuropathy.
• Stresam was also proven to have the ability to alleviate mild depression. However, Stresam is not an antidepressant.
• Stresam has an indirect effect on the course of cardiovascular, pulmonary, gastroenterological, and other psychosomatic diseases.

What are the Side Effects of Stresam?

Stresam is devoid of a significant number of side effects of its precursors (benzodiazepines). Rare side effects include drowsiness, insomnia, and the development of skin allergic reactions.

Can Stresam (Etifoxine) cause weight gain? Indeed many anxiolytics may cause weight increase. But the good news is that etifoxine does not cause weight gain. A recent study on mice even showed that it may actually have the opposite effect (see Ibrahim et al., 2020)!

Where Can I Order Stresam Online?

You can order Stresam (Etifoxine) online at different vendors. CosmicNootropic offers Stresam in packs of 24x50mg and 60x50mg pills with worldwide shipping! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Etifoxine and get it delivered to the USA, Europe, the UK, Asia, and many other destinations via CosmicNootropic.

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All statements on this page are for informational purposes only and have not been evaluated by the US FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Before using Stresam consulting a qualified MD is mandatory. See more

Selank is a peptide anxiolytic from Russia. It is available to buy online at a competitive price.
Original factory-produced high-quality!

Selank Description

What Is Selank?

Selank 0.15% is an anxiolytic peptide with nootropic properties. The main effects include antianxiety, antidepressant, and antiasthenic. By its structure, Selank is based on endogenous tetrapeptide Tuftsin which plays an important role in the immune system.

Selank usually goes in the form of nasal spray or drops.

The History Behind Selank Peptide

Tuftsin was found to have anxiolytic effects in 1995. And over the next decade, Russian scientists were focusing on developing a peptide drug that was able to have the most pronounced anxiolytic effects.

To slow the breakdown of the peptide and prolong its effects, the inventors of Selank added glyproline to its structure. Numerous clinical trials confirmed the safety of this peptide, which was found to be void of dependence and to be non-toxic even in doses 200–500 times higher than therapeutic ones.

This research, as well as clinical trials, lasted until 2009 when Selank was finally brought to market under the brand name Selank 0.15%. It is produced in a GMP-compliant factory by Peptogen Inc. Read more about the producer in this blog post.

How Does Selank Work in the Brain?

The mechanism of the positive therapeutic action of Selank is based on its ability to restore normal levels of serotonin, noradrenaline, and enkephalins in the brain. Further, Selank increases the synthesis of dopamine in the cerebral cortex, which is the basis of stimulating, restoring, and increasing brain activity.

If you want to read more about Selank check out the comprehensive Selank Review in our blog.

Selank and Semax: is there a Difference?

Semax and Selank are two different products. Even though they are both peptides administered nasally, they produce different effects. While Semax is a nootropic and has pronounced stimulating effects, Selank is an anxiolytic. In short, if you are looking for improved focus, mild stimulation, and faster learning – Semax is your choice. Selank will be useful for those looking to release stress, relax, and improve their mood.

What Are the Benefits of Selank Peptide?

The spectrum of the pharmacological action of the drug is wide and unique. It is a popular over-the-counter anti-anxiety medicine with antidepressant and anti-asthenic actions. It also has the capacity to enhance memory and cognitive functions.

Primary Uses of Selank 0.15% nasal drops include:

• Anxiety and adjustment disorders;
• Neurasthenia, emotional lability;
• Stress-related disorders, including GAD, PTSD etc.

Where To Buy Selank Online?

Selank is not FDA-approved, so you will not find it in the US over-the-counter. But you can buy Selank online. There are different forms of Selank: powder, spray, and drops. Make sure to obtain original Selank nasal drops from a trustworthy vendor.

Read more in our in-depth Selank review!

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This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more

What is Picamilon?

Picamilon Sodium (Pikamilon) is a nootropic compound that was synthesized in the USSR in the middle of the 1960s to support brain health and help with anxiety and insomnia. And it has been used as a treatment for neurological problems since then.

Picamilon is based on a synthetic combination of GABA and niacin. This unique blend has been shown to have a variety of benefits for the mind and body. Some of these benefits include improved mood, better brain function, protection against Alzheimer’s disease, and regulation of cerebral blood flow.

Gamma-aminobutyric acid (or GABA) in Picamilon is responsible for reducing neuronal excitability. And niacin acts as a strong vasodilator.

What is Picamilon Used For?

Buy Picamilon to treat the following symptoms and conditions:

• Cerebrovascular diseases;
• Migraine;
• Asthenic disorders (lack of energy);
• Depressions;
• Alcohol withdrawal syndrome.

A well-known biohacker Lucas Aoun reviews Picamilon on YouTube – click below:

As the official instruction claims, Picamilon dilates blood vessels in the brain. It also has tranquilizing, psychostimulating, antiaggregant, and antioxidant effects. Picamilon nootropic improves the functional state of the brain due to the normalization of tissue metabolism and its influence on cerebral circulation. It increases the volume and linear speed of cerebral blood flow, reduces the resistance of cerebral vessels, suppresses platelet aggregation, and improves microcirculation.

After a full treatment course, Picamilon increases physical and mental efficiency, reduces headaches, improves memory, and normalizes sleep. It contributes to the reduction or disappearance of anxiety, tension, and fear. The drug also improves the condition of patients with motor and speech disorders.

Where to Buy Picamilon?

Although it is not a verified dietary supplement in the USA, consumers can easily buy Picamilon online. If you want to purchase Picamilon, buy it at CosmicNootropic. It’s a reliable vendor that offers high-quality nootropics and supplements to improve brain function, reduce anxiety and enhance general well-being.

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All statements on this page are for informational purposes only and have not been evaluated by the US FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Before using Picamilon consulting a qualified MD is mandatory. See more

Please note that Phenibut is not a dietary supplement. The capsules are a medication with a complex effect, which may cause adverse reactions, including severe drug dependence [1] if used incorrectly. 

Find the right phenibut capsules dosage and read all the information about Phenibut online and consult with your doctor before making a purchase. We carry the highest quality original Phenibut to buy.

The maximum order quantity is limited to 3 packs. We also recommend refraining from purchasing Phenibut if you are from Australia or France.

Phenibut Information

What Is Phenibut?

Phenibut is a GABAergic drug with anxiolytic and nootropic effects. It is used in Russia, Ukraine, Kazakhstan and some other countries as a mood elevator, a tranquilizer, and a nootropic for anxiety. Phenibut is a derivative of the naturally occurring inhibitory neurotransmitter Gamma-Aminobutyric Acid, or GABA. An extra phenyl ring makes Phenibut cross the blood-brain barrier much better than the original compound. [2]

Phenibut was synthesized in the USSR in the 1960s by the Soviet chemist and professor Dr Perekalin. Phenibut was recognized for its brain stimulation and anxiety-reducing effects.

Drug to Calm You Down

Phenibut was used by the Russian astronauts to decrease stress and also to maintain high performance levels. It is a known fact that the cosmonauts of the Soyuz-Apollo Space Project had Phenibut in their medical kits.

Phenibut capsules may have a calming effect in small doses and can improve sleep quality along with other positive Phenibut effects. However please remember that Phenibut is a strong medication that should be only used when prescribed by the doctor. Remember that there are safer Phenibut alternatives to support the nervous system, for example: Selank, Afobazole, Mexidol, Stresam as well as other non-medicational methods to reduce stress.

What are Phenibut Uses?

According to the official Phenibut drug sheet and some human research papers mostly conducted in Russia as well as anecdotal Phenibut reviews, the nootropic is said to be beneficial in case of the following symptoms:

• Emotionally labile disorders including post-traumatic stress disorder (PTSD) [3;4];
• Asthenic disorders (lack of energy) [5];
• ADHD [6,7];
• Alcohol withdrawal [8];
• Poor sleep quality [9];
• Other conditions, characterized by reduced intellectual productivity.

What are Phenibut Benefits?

The ability of Phenibut to combine two opposite effects: tranquilizing and activating – makes it a limelight for those who look for a substance with a calming, yet nootropic action. 

Unlike benzodiazepine tranquilizers that have a depressing effect on the CNS and cause reduced performance and attention, Phenibut is said to be void of such side effects if used moderately and under the doctor’s strict supervision. That is one of the reasons why it is widely prescribed by doctors in former Soviet countries to treat ADHD, hyperactivity and lethargy.

What are the Side Effects of using Phenibut Capsules?

When taking Phenibut, it is important to be aware of the potential side effects. The most common adverse reactions to the drug are an increase in irritability, lethargy, dizziness, and nausea. If Phenibut is used for a long time at high doses, a hepatotoxic effect, including fatty liver dystrophy, and eosinophilia may occur because of the Phenibut liver toxicity.

It is also recommended to avoid Phenibut anxiolytic while driving.

View Full Phenibut YouTube Video Review

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Persen® is a combined herbal drug with sedative and antispasmodic effects. It is used when there is no need for a more serious medication. Indications of Persen include neurosis, impaired attention, anxiety, and insomnia. Persen is said to be effective as a replacement therapy after the withdrawal from strong sedatives.

What is Persen?

Persen is a sedative and antispasmodic herbal drug.

It is used to treat neurosis accompanied by stress, impaired attention, anxiety, and insomnia which are usually treated with potent therapy.

It can also be used as a replacement therapy after the withdrawal of strong sedatives. Persen can be prescribed for the prevention of psychosomatic disorders caused by stress. It has also proved to be effective in dysautonomia treatment.

What are the Benefits and Side Effects of Persen?

• Valerian root and rhizome extract have a calming effect.
• Lemon balm (Melissa officinalis) leaf extract has a soothing and antispasmodic effect.
• Peppermint leaf extract has antispasmodic and moderate sedative effects.

What is Persen Used For?

Indications of Persen include:

• Increased nervous irritability and excitability;
• Insomnia;
• As a part of complex therapy of dysautonomia.

Where Can I Order Persen Online?

You can buy Persen online from different vendors. CosmicNootropic offers Persen in packs of 20 pills and 60 pills. We offer worldwide shipping! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Persen and get it delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.

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This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
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Peony anomala tincture is a herbal sedative medicine. Peony anomala (Maryin root) is a perennial herbaceous plant. Its roots contain essential oils, digestible carbohydrates, vitamin C, benzoic acid, sitosterol, terpenoids, tannins, potassium, calcium, and manganese. Its aerial part contains glycosides, bioflavonoids, and tannins and its seeds are rich in fatty oils. The plant was widely used in Chinese, Mongolian, and other traditional medicines to treat gastrointestinal diseases, malaria, fever, and as a sedative drug, and even as an antidote for poisonings. It belongs to the group of natural adaptogens, the means that stimulate the immune system.

The tincture is used as a sedative and a natural hypnotic in patients with sleep disorders, the excitability of the nervous system, and dysautonomia. Buy Peony anomala tincture to stimulate endorphin production and help to cope with stress and emotional overload. It can also be used as part of complex therapy for chronic alcoholism and hormonal imbalance during menopause and in order to relieve cramps, involuntary spasms, and contractions in patients with epilepsy. Moreover, the tincture has been proven to have antispasmodic and anti-inflammatory effects.

Produced in Russia.

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Hopantenic acid (Pantogam) is a nootropic structurally similar to vitamin B5 (pantothenic acid). It has nootropic, anxiolytic and anticonvulsant effects. Pantogam is used to boost physical performance and improve memory and attention.

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What is Hopantenic Acid?

Pantogam (Hopantenic acid) is a nootropic drug with anxiolytic action.

The molecule of hopantenic acid is obtained by substituting the beta-alanine moiety of pantothenic acid (vitamin B5) for gamma-aminobutyric acid (GABA). Unlike GABA itself, Pantogam can cross the blood-brain barrier and produce a GABAergic effect.

Pantogam was first synthesized in the 1950s by Japanese scientists. Since 1977 in Russia and since 1978 in Japan, it is used in medicine to treat various neurological disorders in children and adults, including autism.

The drug has nootropic, anxiolytic and anticonvulsant effects. Pantogam interacts with GABA-A, GABA-B, and dopamine D2 receptors and stimulates acetylcholine synthesis.

What is the Difference Between Pantogam and Pantogam Active?

Pantogam Active (D-, L-Hopanthenic acid) is the racemic modification of the original drug; this modification was developed by the Russian pharmaceutical company “Piq-Pharma” in 2008. Its active substance Calcium hopantenate has two active isomers with different pharmacology, and Pantogam Active has a higher content of L-hopantenic acid than Pantogam. Because of the ratio of the different isomers in these two drugs, they differ in both effects and efficacy.

Pantogam Active exhibits more pronounced anxiolytic, anti-amnesic, and anticonvulsant effects and can be used long-term without forming an addiction.

What is Hopantenic Acid Used For?

Intended uses of Pantogam (Hopantenic acid) include:

• Organic brain syndrome;
• Cerebrovascular insufficiency;
• Extrapyramidal symptoms;
• Epilepsy;
• Decreased mental and physical capacity;
• Neurogenic bladder dysfunction;
• Developmental delays.

You can also use Pantogam in healthy individuals to increase mental and physical capacity and relieve chronic fatigue. It also may improve memory and attention.

Where Can I Order Hopantenic Acid Online?

You can buy Hopantenic Acid online from different vendors. CosmicNootropic offers Hopantenic Acid (Pantogam / Pantogam Active) in packs of 50x250mg pills and 60x300mg capsules. We offer worldwide shipping with volume discounts! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Hopantenic Acid (Pantogam / Pantogam Active) and get it delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.

We also sell a similar product – Pantocalcin.

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Pantocalcin is a nootropic drug with neuroprotective, neurometabolic, and neurotrophic properties. Its active ingredient is the calcium salt of hopantenic acid. Pantocalcin can contribute to the normalization of brain function at the level of individual neurons and their synaptic connections. It is used to improve memory, perception, attention, and thinking, increase learning ability, and activate intellectual functions.

What is Pantocalcin?

Pantocalcin is a nootropic drug that is used in the treatment of various neurotic disorders and psychoemotional stress. The active ingredient Hopantenic acid has neuroprotective, neurometabolic, and neurotrophic properties. Pantocalcin, the calcium salt of hopantenic acid with all the properties of this acid, contributes to the normalization of brain function at the level of individual neurons and their synaptic connections in various pathologies.

Hopantenic acid (N-pantoyl-GABA) is the higher homolog of D(+)-pantoyl-g- aminobutyric acid (vitamin B5), in which β-Alanine is replaced by γ-aminobutyric acid (GABA). This substance was first synthesized by Japanese researchers in the early 1950s as a part of research on pantothenic acid analogs; then, it was found to be present in the brain of various animal and plant tissues. Subsequent pharmacological study of this compound was conducted in Japan and later in the Soviet Union.

Read the transcript of the interview in our blog.

What are the Benefits and Effects of Pantocalcin?

Hopantenic acid is a natural mediator of GABA in the nerve tissue, unlike other GABA-derived nootropic drugs. Hopantenic acid penetrates the blood-brain barrier and has a pronounced effect on the functional activity of the CNS due to the presence of pantoyl radical in its molecule.

Hopantenic acid has many points of application in cellular metabolism and it determines its wide spectrum of pharmacological actions:

• The drug improves glucose utilization (especially in the cerebral cortex, subcortical ganglia, hypothalamus, and cerebellum), and nucleic acid metabolism.
• It also activates the synthesis of ATP, protein, and RNA, i.e. stimulates anabolic processes in the brain neurons.
• The indirect neurometabolic effect of the drug is associated with the improvement of microcirculation in the brain due to the optimization of the passage of red blood cells through the vessels of the microvasculature and inhibition of platelet aggregation.
• The drug has an anti-hypoxic effect – it can reduce neuronal oxygen demand under hypoxic conditions;
• It has a neuroprotective effect – it can increase the resistance of nerve cells to adverse factors;
• The drug also has an antiepileptic effect;
• It can facilitate information transfer in the brain, enhance wakefulness, and amplify the absolute and relative power of the EEG spectrum of the cortex and hippocampus. Improved informational exchange in the brain results in improved memory, perception, attention, thinking, increased learning ability, and activated intellectual functions.

What is Pantocalcin Used For?

In the indications listed below Pantocalcin is usually used as a part of complex therapy and not as the first drug of choice.

The on-label use of Pantocalcin includes the following indications:

• Cognitive impairment in organic brain lesions and neurotic disorders;
• Cerebrovascular insufficiency caused by atherosclerotic changes in cerebral vessels, senile dementia (initial form), and residual organic brain lesions in persons of mature age and in the elderly;
• Cerebral organic insufficiency in patients with schizophrenia;
• Extrapyramidal hyperkinesis in patients with hereditary diseases of the nervous system (Huntington’s chorea, hepatocerebral dystrophy, Parkinson’s disease, etc.);
• The consequences of previous neuroinfectious and traumatic brain injuries;
• Correction of side effects caused by neuroleptics or preventively as a so-called “add-back therapy”;
• Epilepsy with a slowdown of mental;
• Psychoemotional stress, reduced mental and physical performance as well as problems with concentration and memory;
• Urination disorders: enuresis, daytime urinary incontinence, pollakiuria, and urinary urgency;
• Children with mental retardation e.g. delay in mental, speech, and motor development, infantile cerebral palsy, stuttering (mainly clonic form), and epilepsy.

Where Can I Order Pantocalcin Online?

You can buy Pantocalcin online at different vendors. CosmicNootropic offers Pantocalcin in packs of 50x250mg pills and 50x500mg pills. We offer worldwide shipping! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Pantocalcin and get it delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.

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Motherwort tincture is a well-known natural herbal supplement that has been used in Chinese and European traditional medicine for hundreds of years.

Motherwort or Leonurus cardiaca is used as a sedative. Motherwort is often compared to Valery, noting that its effect is even stronger than the latter. Among other things, motherwort tincture produces a tonic effect, reduces the heart rate, which is very important for people involved in sports. Motherwort tincture can reduce blood glucose levels, which is important for people with diabetes.

Pharmacological properties

This is a supplement of herbal origin, it is 100% natural. It has a sedative, hypotensive and cardiotonic action. Motherwort tincture influences some of the functions of the central nervous system 2-3 times more strongly compared to valerian tincture. The therapeutic effect is manifested during the systematic and long-term course of treatment.

Buy Motherwort as a sedative supplement to heal:

• Neurotic disorders, accompanied by sleep disturbance;
• Neurosis and vegetative-vascular dystonia;
• Vegetative neurosis of the pre-menopausal period, accompanied by high blood pressure, tachycardia, and cardiac pain;
• Increased excitability.

Produced in Russia.

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To be used as a dietary supplement. 

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What is Mexidol?

Mexidol is an inhibitor of free-radical processes and membrane protector with anti-hypoxic, stress-protective, nootropic, anticonvulsant, and anxiolytic action.

It is a unique development of the Russian pharmaceutical industry. The development of Emoxypine (Mexidol) is closely associated with the name of the Soviet chemist NN Semenov, who was awarded the Nobel Prize in Chemistry. The drug has been in clinical practice since the 1990s. Click on Research tab above and find a lot of Mexidol research papers.

What is Mexidol Pharmacology?

Mexidol has antioxidant, anti-hypoxic, and membrane-protective properties. The presence of succinate in the structure of Mexidol is of fundamental importance for the manifestation of its pharmacological effects, since succinate is functionally significant for many processes in the body. In particular, it is a substrate for increasing the energy metabolism in the cell. Due to its properties, free radicals, which have a damaging effect on cellular structures, are deactivated.

Mexidol reduces the viscosity of the membrane and increases its fluidity. The drug preserves the structural and functional organization of membranes and improves synaptic transmission. It enhances the compensatory activation of aerobic glycolysis and activates the energy-synthesizing functions of mitochondria.

In conditions of coronary insufficiency, the drug increases the collateral blood supply of the ischemic myocardium, preserves the integrity of cardiomyocytes, and maintains their functional activity.

What are the Benefits of Mexidol?

• Mexidol improves the blood supply of the brain, improves rheological properties of blood, and reduces platelet aggregation.
• The drug lowers the level of total cholesterol and low-density lipoproteins.
• Mexidol exhibits anti-stress action, normalizes somatic-vegetative disorders and restores sleep-wake cycles.
• It can restore disrupted learning and memory processes, and reduces dystrophic and morphological changes in various structures of the brain, improving congitive functions.
• Mexidol has a pronounced antitoxic effect in patients with a withdrawal syndrome. It eliminates neurological and neurotoxic manifestations of acute alcohol intoxication.
• Mexidol improves the functional state of the ischemic myocardium.

An important advantage of Mexidol is that it stacks well with most nootropics, for example Meldonium. Besides, Mexidol enhances the effect of tranquilizers, neuroleptics, antidepressants, hypnotics, and anticonvulsants. Thus with Mexidol it is possible to reduce their doses and diminish some side effects.

What is the Intended Uses of Mexidol?

Mexidol is effective in the treatment of acute and chronic diseases caused by ischemia and hypoxia. Mexidol is known to treat the followings diseases:

• Neurology: vegetovascular dystonia, acute cerebral circulation disorders, cognitive problems associated with cerebral arteriosclerosis (impaired memory, speech, loss of basic skills, etc.), traumatic brain injury;
• Cardiology:  for the complex treatment of ischemic heart disease;
• Psychiatry: withdrawal syndrome (alcohol or drug withdrawal), anxiety disorders, neurosis, intoxication with drugs from the group of antipsychotics;
• Surgery: for the complex treatment of acute purulent-inflammatory processes in the peritoneum.

Where Can I Order Mexidol Online?

You can buy Mexidol (Emoxypine) online from different vendors. CosmicNootropic offers Mexidol in packs of 30x125mg pills or 10x2ml vials. We offer worldwide shipping with volume discounts! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Mexidol and get it delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.

In our store you can also find several analogues of Mexidol, namely Ethoxidol and BrainMax. Be sure to check them out and choose which one works best for you!

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Metadoxine is a hepatoprotective and detoxification drug. This medication is used to treat chronic and acute alcohol intoxication, quit alcohol addiction, and restore liver functions. It can speed up detoxification of the body, neutralize the action of alcohol, and protect liver cells.

What is Metadoxine?

Metadoxine is a medicine designed to restore and maintain a healthy liver. The drug helps to prevent many diseases and negative consequences associated with the regular intake of alcoholic beverages. Initially, this Italian drug was created as a means to treat teenage alcoholism, but then it became widely used for the treatment of adults. The active substance of the drug is metadoxine which is a more active derivative of pyridoxine (vitamin B6). The drug helps detoxify the body by speeding up the process of elimination of alcohol and its decay products from the body. In prolonged use, the drug helps protect the liver, as it increases the resistance of liver cells to toxic substances.

What Does Metadoxine Do to The Body?

Metadoxil or Metadoxine (as it is called in international practice) may protect liver cells from destruction and act as a hepatoprotector. Alcohol is able to dissolve the fatty membrane of hepatocytes (liver cells) and destroy them. Metadoxine enters into biochemical reactions with fatty acids, neutralizing the action of alcohol. As a result, the resistance of liver cells to the action of toxic substances (ethanol and acetaldehyde – the toxic product of its decay) is significantly increased.

Metadoxine may accelerate the detoxification process of the body, enhancing the production of enzymes that decompose toxins. Therefore, alcohol and acetaldehyde are excreted faster. It may also reduce the craving for alcohol and slow down the development of cirrhosis, as it accelerates the elimination of substances that contribute to the growth of fibrous tissue because of the death of hepatocytes. Besides, it may accelerate the process of getting out of a hangover.

Due to rapid detoxification, Metadoxine weakens the effect of ethanol on the brain and central nervous system. Due to this property, the mental and physical manifestations of withdrawal symptoms are relieved and the symptoms of a hangover (headache, nausea, vomiting, dizziness, bone pain) are eliminated. Appetite, sleep, and mood are being improved. The feeling of anxiety and fear goes away.

Metadoxine can be used to improve memory and ability to think impaired after alcohol consumption. It may reduce nervous system agitation and eliminate hand tremors thus acting as an antidepressant.

Where Can I Order Metadoxine Online?

You can buy Metadoxine online at different vendors. CosmicNootropic offers Metadoxine (Metadoxil) in packs of 10x5ml vials and 30x500mg pills. We offer worldwide shipping! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Metadoxine and get it delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.

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Magne B6 ® is a supplement that combines benefits of Magnesium and vitamin B6. Magnesium is a vital element that participates in most metabolic reactions and the transmission of nerve impulses. It has antispasmodic, antiarrhythmic and antiplatelet effects.

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What is Magne B6?

Magne B6 ® is a drug with two active ingredients – Magnesium and vitamin B6 – intended to restore the amount of magnesium in the body.

Magnesium is the eleventh most abundant element by mass in the human body and is essential to all cells and some 300 enzymes. Magnesium ions interact with polyphosphate compounds such as ATP, DNA, and RNA. Hundreds of enzymes require magnesium ions to function. It is engaged in the transmission of nerve impulses and muscle contraction. Normal levels of magnesium are important for the maintenance of heart and nervous system function.

Pyridoxine (vitamin B6), one of the drug’s main ingredients, participates in various metabolic processes, and in regulating the metabolism of the nervous system, in particular. It improves magnesium absorption from the digestive system into the body’s cells.

What are the Benefits and Effects of Magne B6?

Magnesium deficiency may occur as a result of eating disorders (including reduction diets) and an increased need for magnesium in case of intense physical or mental activity, stress, pregnancy, or the use of diuretics. Losses of magnesium from the kidneys also become a common cause of magnesium deficit. The normal adult value for magnesium is 1.5–2.5 mEq/L. Smaller amounts are evidence of magnesium deficiency, also known as hypomagnesemia. It may cause fatigue or muscle weakness, mental numbness, and lack of emotion. Scientists have suggested that deficiency may also cause anxiety and raise blood pressure.

What is Magne B6 Used For?

Magne B6 is used in cases of magnesium deficiency (might be in combination with other deficiencies) which often has the following symptomswith increased irritability, sleep disorders, stomach cramps, palpitations, fatigue, pain and muscle cramps, or tingling sensation.

Where Can I Order Magne B6 Online?

You can buy Magne B6 online at different vendors. CosmicNootropic offers Magne B6 in packs of 60x(48mg+5mg) pills. We offer worldwide shipping with volume discounts! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Magne B6 and get it delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.

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Jujube, lotus, longan, thuja, and coral tree extracts have a sedative effect and reduce irritation and tension that occur as a result of mental fatigue and neurasthenia. In patients with insomnia, they help restore normal sleep. Jujube seeds and leaves have been used in Chinese and Korean traditional medicine, where they were believed to alleviate stress, and traditionally for anti-fungal, anti-bacterial, anti-ulcer, anti-inflammatory purposes and sedation, antispastic, antifertility/contraception, hypotensive and antinephritic, cardiotonic, antioxidant, immunostimulant, and wound healing properties.

Apart from having a sedative effect, dioscorea, mulberry, and longan extracts also cause vasodilation and boost metabolism.

Indications

• Increased excitability, irritability, mood lability, emotional and physical injuries, tension, mental fatigue, and mild forms of insomnia.

Produced by Danapha Pharmaceutical, Vietnam.

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Intellan is a powerful brain tonic that contains a natural blend of vital amino acids, trace elements, alkaloids, and glycosides. Being natural neurostimulants, the active substances that make up the drug activate neurons, enhance metabolic processes in the brain and improve blood circulation in the vessels. Buy Intellan to improve memory, mild mood depression, and dizziness.

Medicinal plants of Intellan are:

• Ginkgo Biloba has a nootropic and powerful antioxidant effect. Improves cerebral circulation and the supply of oxygen and glucose to the brain. Helps reduce hypoxia and normalize metabolic processes in brain cells. These properties of Ginkgo Biloba are especially important for people engaged in intellectual work, as they allow stimulating mental activity, memory, and attention. They also contribute to the correction of age-related changes in the functional activities of the brain, accompanied by memory impairment, decreased concentration of attention and intellectual abilities, dizziness, “noise” and “ringing” in the ears.

• Asiatic Pennywort (Centella Asiatica or Gotu Kola) has a special place in oriental medicine. It is called “brain food” because its active components (triterpene glycosides, bacosides, and flavonoids) contribute to increased mental performance, concentration, long-term memory function, and learning ability, as well as to normalization of the psycho-emotional state in case of increased anxiety and stress.

• Herpestis Monnieria is a rich source of amino acids (including glycine, which is a metabolic regulator that normalizes and activates the processes of protective inhibition in the central nervous system). Glycine helps to reduce psycho-emotional tension (during exams, stresses, conflict situations, etc.), fatigue, and to improve mood.

• Coriandrum Sativum has an antispasmodic effect and is a source of macroelements (potassium, magnesium, calcium) and microelements (including selenium which has the ability to bind free radicals).

• Emblica Officinalis (Phyllanthus Officinalis) improves functions of the cardiovascular system and acts as a source of vitamin C (antioxidant), vitamins B1 and B2, and nicotinic acid.

• Bengal Cardamom helps to increase the overall tone of the body.

Thus, the action of each of the components is multidirectional, and their overall effectiveness is due to the thorough selection of the components through research and strict dosage.

Indications

• Deficient memory and forgetfulness;
• Lack of concentration and disorientation;
• Mental stress, strain, and fatigue;
• Functional cerebral insufficiency;
• Mild anxiety and depression.

Produced by Herbion, Pakistan.

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Tofisopam (Grandaxin) is an anti-anxiety medication produced in Hungary and available in several European countries. It is a daytime anxiolytic as it does not have sedative, skeletal muscle relaxant, motor skill-impairing, anticonvulsant or amnestic properties.

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What is Tofisopam (Grandaxin)?

Grandaxin (Tofisopam) is a non-sedating anxiolytic drug with unique pharmacological action. Tofisopam was first synthesized in 1966 in Hungary and is successfully used for anxiety management since the 1970s.

Tofisopam, the active substance of Grandaxin, is a benzodiazepine tranquilizer. Its pharmacological action differs from that of typical benzodiazepine derivatives. Tofisopam belongs to the 2,3-benzodiazepines family, a unique class of psychoactive substances also known as homophthalazines. Unlike 1,4- benzodiazepine derivatives (e.g. Diazepam), Tofisopam does not have sedative and anticonvulsant properties and causes almost no physical or psychological dependence or withdrawal syndrome.

As of today, Grandaxin is used in 15 countries across the world, including Russia, Japan, Hungary, and the Czech Republic. Although this drug is not approved for use in North America, its R-enantiomer is in stage II clinical trials for the treatment of irritable bowel syndrome.

Grandaxin review by Boost Your Biology Expert – Lucas Aoun!

What Does Tofisopam Do?

Tofisopam, the active substance of Grandaxin, has a complicated mechanism of action. It does not bind to benzodiazepine receptors and has a limited affinity to the peripheral benzodiazepine receptors, but it improves the binding of 1,4-benzodiazepines to their receptors. The main effects are due to the stimulation of benzodiazepine receptors in the brain, its excitation leads to an increase in the sensitivity of GABA receptors to the mediator. As a result, GABA-ergic transmission is enhanced: chloride channels work more intensively, hyperpolarization of neuron membranes increases, and neuronal activity decreases.

Several studies suggest that the behavioral effects of Grandaxin are likely to be mediated through its effect on dopaminergic and opioid neurotransmission. Tofisopam may enhance the sensitivity of dopamine receptors and modulate opioid signal transduction in the brain without the danger of addiction.

The drug acts as a phosphodiesterase (PDE) inhibitor with the highest affinity to PDE-4A1, PDE-10A1, PDE-3, and PDE-2A3 which can be responsible for its moderate antipsychotic action.

Grandaxin (Tofisopam) does not impair cognitive functions, you can buy it for its mild stimulant action and the ability to potentiate the effect of dopaminergic stimulants.

What is Tofisopam (Grandaxin) Used For?

Grandaxin is prescribed in the following cases:

• Neurosis, psychopathy, and other conditions accompanied by a feeling of emotional stress, anxiety, and fear;
• Reactive depression with mild psychopathic symptoms;
• Premenstrual syndrome, climacteric syndrome;
• Cardialgia (in the form of monotherapy or in combination with other drugs);
• Myasthenia gravis, myopathies, neurogenic muscular atrophies, and other pathological conditions with secondary neurotic symptoms, when anxiolytics with a pronounced muscle relaxant effect are contraindicated; alcohol withdrawal syndrome.

A course of Grandaxin can also be used for alcohol withdrawal.

Where Can I Order Tofisopam (Grandaxin) Online?

You can order Grandaxin online from different vendors. CosmicNootropic offers Grandaxin in packs of 20x50mg and 60x50mg tablets with worldwide shipping! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Grandaxin and get it delivered to the USA, Europe, the UK, Asia, and many other destinations via CosmicNootropic.

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Biotredin (L-Threonine + Vitamin B6) is a nootropic that improves metabolism and boosts cellular energy. The drug is comprised of L-threonine and pyridoxine hydrochloride (vitamin B6). Biotredin is mainly used for treating alcohol dependency and improving concentration.

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What is Biotredin?

Biotredin is a nootropic medication that improves metabolism and boosts cellular energy. The drug is comprised of L-threonine and pyridoxine hydrochloride (vitamin B6). Together, threonine and vitamin B6 interact to form the amino acid glycine and acetaldehyde. The resulting substance promotes active stimulation of inhibitory processes, oxidation-reduction, and supports respiratory function, and synthesis of adenosine triphosphate in the cells.

Biotredin pills gained wide exposure primarily as an effective and safe drug for treating alcohol dependency. Doctors believe the main advantage of Biotredin over other similar drugs is that it is fast-acting and can be used to treat patients of any age. Some even claim that it can help with the hangover!

The unique combination of threonine and pyridoxine has a synergetic effect on the improvement of brain function.

Although Biotredin can treat psychological strain and stress, it is not a sedative. In other words, Biotredin does not suppress the central nervous system. Therefore, it does not cause dependency or lethargy.

L-threonine and vitamin B6 are natural substances for living organisms. L-threonine is а structural element of the central nervous system and is an essential amino acid the human body cannot synthesize on its own.

What is the Mechanism of Action of Biotredin?

After placing the tablet under the tongue, the body absorbs L-threonine and pyridoxine into the blood. Threonine is then broken down into glycine and acetaldehyde (pyridoxine works as a catalyzer). Acetic acid and glycine stimulate the synthesis of adenosine triphosphate (ATP) in cells, redox, and cellular respiration.

What are the Benefits and Effects of Biotredin?

L-threonine has the following biological effects on the body:

• It activates metabolism in tissue;
• It strengthens intellectual qualities;
• It can increase general productivity;
• It can alleviate psycho-emotional stress;
• It can treat alcoholism and relieve symptoms of withdrawal syndrome.

What is Biotredin Used For?

Biotredin is prescribed in the following cases:

• Concentration problems and poor task performance;
• Treating various stages of alcoholism;
• Managing symptoms of a withdrawal syndrome in patients with alcohol dependency;
• Irritability and depression;
• Treatment during remission.

Where Can I Order Biotredin Online?

You can buy Biotredin (L-Threonine + Vitamin B6) pills online at different vendors. CosmicNootropic offers Biotredin in packs of 30x(100mg+5mg) pills . We offer worldwide shipping with volume discounts! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Biotredin and get it delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.

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Afobazole, also known as Fabomotizole, is a selective non-benzodiazepine anxiolytic launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions.

What is Afobazole?

Fabomotizole (brand name Afobazole) is a novel anxiolytic drug with nootropic properties used to treat anxiety and some cardiac disorders. One of the most important advantages of Fabomotizole over benzodiazepines is that it does not form dependence and has fewer side effects.

Afobazole was discovered at the beginning of the 2000s in Russia at the Zakusov Institute of Pharmacology. This institute is also known for its discovery of Noopept, Ladasten (Bromantane), and Selank. Afobazole is a popular anxiolytic that it can be bought over the counter in almost every Russian pharmacy.

What makes Afobazole so special among other anti-anxiety medications? – Afobazole does not have sedative, hypnotic, or muscle relaxant action. Along with that, it does not form dependence in any dosage. Besides that, Afobazole studies in models of local and global ischemia have revealed the neuroprotective effects of the drug.

What is the Afobazole Mechanism of Action?

Afobazole’s mechanism of action is different from that of benzodiazepines. It is not a benzodiazepine receptor site agonist; at the same time, it prevents stress-induced changes in the GABA-benzodiazepine receptor complex and restores its sensitivity to endogenous inhibitory mediators. The drug acts on σ1 receptors, melatonin MT1 and MT3 receptors, and was shown to reversibly inhibit MAO-A.

Afobazole also increases the bioenergetic potential of neurons, and restores and protects nerve cells. Besides, it has some neurotrophic properties, although they are not as pronounced as in Stresam another non-sedative anxiolytic. In studies on rats, Afobazole prevented stress-induced BDNF decrease and it increased NGF and BDNF content in hippocampal HT22 cells culture.

What are Afobazole’s Benefits and Effects?

The benefits of the drug are achieved mostly through the combination of its anxiolytic and light-stimulating effects.

Afobazole reduces:

• anxiety, bad foreboding, and fears;
• irritability, tension (fearfulness, tearfulness, anxiety, inability to relax, insomnia, and fear);
• depressive mood, somatic manifestations of anxiety (muscular, sensory, cardiovascular, respiratory, and gastrointestinal symptoms);
• autonomic disorders (dry mouth, sweating, and dizziness);
• cognitive disorders (difficulty concentrating and poor memory), including those arising from stress.

The treatment is usually well-tolerated by the patients. The drug is not habit-forming and does not cause withdrawal after cessation.

What is Afobazole Used for?

Afobazole (Fabomotizole) is used to treat the following symptoms:

• Generalized anxiety disorder symptoms, e.g. bad feelings, tensions in the body, irritability, tearfulness, fearfulness, etc.;
• Adjustment disorders;
• Various somatic (psychophysiological) disorders, e.g. asthma, irritable bowel syndrome, systemic lupus erythematosus, ischemic heart diseases, etc.;
• Sleep disorders caused by anxiety;
• Premenstrual syndrome;
• Alcohol withdrawal and nicotine withdrawal syndrome;
• Neurocirculatory dystonia;
• Neurasthenia;
• Premenstrual syndrome.

Where Can I Order Afobazole Online?

You can order Afobazole online from different vendors. CosmicNootropic offers Afobazole in packs of 30x10mg and 60x10mg pills with worldwide shipping! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Afobazole and get it delivered to the USA, Europe, the UK, Asia, and many other destinations via CosmicNootropic.

Check other products from the ANTI-ANXIETY category.

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What is GABA (Aminalon)?

Aminalon is a substance with nootropic and psychostimulatory qualities. Gamma-Aminobutyric acid is the only active component in this drug. Aminalon is a neurotransmitter that slows nerve impulses. Gamma-Aminobutyric acid (also known as GABA, γ-aminobutyric acid) is synthesized in the brain from glutamic acid (another neurotransmitter) through decarboxylation (a chemical reaction that removes a carboxyl group and releases carbon dioxide). You can always buy Aminalon pills from our stock!

Researchers discovered Gamma-Aminobutyric acid in 1950. It was marketed in Japan in the 1960s under the name Gammalon. The drug then appeared in the USSR in the 1970s as Aminalon.

What is the Mechanism of Action of GABA (Aminalon)?

Aminalon is a nootropic that restores metabolic processes in the brain, regulates the brain’s use of glucose, and works to remove metabolic toxins. It improves thinking and memory and restores motor and speech functions after problems caused by insufficient blood flow to the brain. It has a light tension booster effect, lowers arterial pressure, and alleviates symptoms of hypertonia (dizziness and insomnia). GABA slightly reduces heart rate. It also has a moderate anti-hypoxic and anticonvulsant effect.

It can lower glucose levels in people with diabetes and produces the opposite effect in those with normal glucose levels.

Aminalon is quickly absorbed. Its half-life is 60 minutes, then the concentration quickly lowers. After 24 hours Aminalon is not detectable in plasma.

What are The Benefits and Effects of GABA (Aminalon)?

The main property of GABA is that it regulates blood flow in the brain and improves memory, speech, and coordination. It increases oxygen levels in nerve tissue and protects against convulsions. GABA facilitates the absorption of glucose. It can also lower blood pressure, regulate sleep, and remove toxic metabolites.

It facilitates cerebral metabolic processes. It works thanks to the interaction between its active element and specific receptors in the brain. As a result, blood flow to the brain normalizes, as well as cellular respiration and energy production. GABA works to remove toxic substances and harmful metabolic products while regulating the body’s use of glucose. This leads to an overall regulation of CNS processes.

Amonalon is said to improve memory and thinking as well as recovery of speech and motor skills lost due to reduced blood flow to the brain. Additionally, the active component of the drug stabilizes arterial pressure, alleviating unpleasant symptoms such as interrupted sleep, vertigo, and convulsions. Patients suffering from diabetes notice lowered blood sugar after taking the drug.

What is Aminalon Used For?

Aminalon (GABA) is used in the following cases:

• Atherosclerosis of cerebral arteries accompanied by mental deterioration;
• Arterial hypertension;
• Symptoms from the head and brain trauma and circulatory problems in the brain;
• Cerebral blood vessel disease, especially when accompanied by head pain and vertigo;
• Memory, speech, and attention problems as a result of chronic cerebrovascular illness;
• Alcoholic polyneuropathy and encephalopathy;
• Seasickness;
• Intellectual disability and developmental delay;
• Children’s cerebral palsy;
• Seasickness.

Where Can I Order GABA (Aminalon) Online?

You can buy GABA pills online from different vendors. CosmicNootropic offers GABA (Aminalon) in packs of 50x250mg pills. We offer worldwide shipping with volume discounts! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order GABA (Aminalon) and get it delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.

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This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more

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What is Mebicar?

Mebicar is a daytime tranquilizer. Mebicar belongs to a group of non-benzodizepam tranquilizers. From the chemical perspective, it is a derivative of carbamide, an endogenous metabolite, which explains why the compound is 150 times less toxic than Diazepam.

What is the Mechanism of Action of Mebicar?

Mebicar affects the emotiogenic zones of the hypothalamus. It has an effect on 4 major neurotransmitter systems: GABAergic, cholinergic, serotonergic, and adrenergic. It contributes to their balance and integration without a peripheral adrenoceptor-blocking effect.

It decreases brain norepinephrine levels and increases brain serotonin levels without modulating dopaminergic systems or cholinergic systems.

Here you can find the script of the video.

What are the Benefits and Effects of Mebicar?

• Mebicar can prevent and reduce anxiety, fear, tension, and irritability. Its anxiolytic effect is not accompanied by muscle relaxation, impaired coordination of movements, an elevated mood, a feeling of euphoria, or reduced mental or physical activity, so Mebicar can be used during the daytime.
• Mebicar can enhance the effect of hypnotics and improve disturbed sleep.
• Mebicar is said to relieve nicotine withdrawal.
• Mebicar has a nootropic effect. It improves cognitive functions, attention, and mental performance without stimulating delirium or pathological emotional activity.

What is Mebicar Used For?

You can use Mebicar to treat the following symptoms:

• Asthenic disorders;
• Depressions with anxiety;
• Various conditions characterized by reduced mental productivity;
• Extreme work conditions, e.g. excessive mental or physical exertion;
• Nicotine withdrawal;
• Impaired memory formation.
  

Where Can I Order Mebicar Online?

You can buy Mebicar online from different vendors. CosmicNootropic offers Mebicar in packs of 20x300mg pills and 20x500mg pills. We offer worldwide shipping with volume discounts! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Mebicar and get it delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.

Legal Disclaimer
This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more